CORDIS Project
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This project investigates the role of damage-associated molecular patterns in inflammation, particularly focusing on extracellular actin as a potential signaling molecule. Using Drosophila as a model organism, it aims to identify the molecular sensors involved in the inflammatory response to tissue damage.
Inflammation is a host response that evolved to counteract noxious stimuli that result from infection or tissue injury, and serves to return the affected tissue to homeostasis.
Cell death-associated sterile inflammation is a major contributor to secondary tissue damage associated with multiple conditions such as myocardial infarction, transplantation, and stroke.
Damaged tissues are thought to elicit their inflammatory effects through the sudden release from cells of endogenous Damage-Associated…
THE FRANCIS CRICK INSTITUTE LIMITED
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