CORDIS Project
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This project explores the role of actin in regulating the SRF transcriptional coactivator, MAL. It aims to uncover the molecular mechanisms of actin's influence on gene expression and the dynamics of actin-related processes in the cell nucleus.
MAL: an actin-regulated SRF transcriptional coactivatorRecent years have seen a revitalised interest in the role of actin in nuclear processes, but the molecular mechanisms involved remain largely unexplored.
We will elucidate the molecular basis for the actin-based control of the SRF transcriptional coactivator, MAL. SRF controls transcription through two families of coactivators, the actin-binding MRTFs (MAL, Mkl2), which couple its activity to cytoskeletal dynamics, and the ERK-regulated TCFs…
THE FRANCIS CRICK INSTITUTE LIMITED
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