CORDIS Project
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This research focuses on understanding actin nucleation mechanisms and their role in cellular processes. By determining the three-dimensional structures of actin nucleators, the project aims to elucidate their functions and potential clinical applications.
Actin is one of the most conserved globular proteins among diverse species.
It plays a major role in many important cellular processes that range from muscle contraction, cell motility, cell division and cytokinesis to vesicle/organelle-movement, cell signaling, maintenance of cell junctions and shape.
Actin filaments are major determinants of cell morphology and are sites for focal adhesion in multicellular organisms.
Actin filaments nucleate from free actin monomers to form oligomeric assembli…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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