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The PROMICO project investigates how physical confinement affects cell behavior, particularly in cancer research. By developing innovative micro-fabrication techniques, it aims to create tools for studying cell dynamics and improving applications in cell therapies and drug screening.
In tissues, cells have their physical space constrained by neighbouring cells and extracellular matrix.
In the PROMICO ERC project, our team proposed to specifically address the effect of physical confinement on normal and cancer cells that are dividing and migrating, using new pathophysiologically relevant in vitro approaches based on innovative micro-fabrication techniques.
One of the devices we developed was meant to quantitatively control two key parameters of the cell environment: its geome…
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