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The ACT-SIGNAL project aims to clarify the role of lysine acetyltransferases in gene activation during transcription. By combining gene editing and proteomics, it seeks to establish a model for how acetylation influences gene regulation.
Transcription, the first and most crucial step in decoding the genome, is orchestrated by an extensive repertoire of transcription factors (TFs).
These TFs transmit diverse signals to the nucleus, directing precise temporal and spatial gene activation programs.
They employ a diverse array of transcription coactivators to impact transcription, including lysine acetyltransferases (KATs), an evolutionarily conserved group of coactivators found in all eukaryotes.
Lysine acetylation serves as a hallm…
KOBENHAVNS UNIVERSITET
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