CORDIS Project
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This project focuses on developing a novel peptide, TAX2, that targets the extracellular matrix in solid tumors to inhibit cancer progression and enhance the effectiveness of existing therapies. The approach aims to overcome barriers posed by the tumor microenvironment, particularly in ovarian cancer.
Cancer is the second biggest cause of death worldwide. 90% of cancers are solid tumours, where tumour stromal cells secrete a dense mass of proteins called the extracellular matrix (ECM), part of a protective tumour microenvironment that promotes cancer proliferation, invasiveness, and resistance to chemotherapy and biologics.
Several therapies now available or being developed rely on monoclonal antibodies aimed at tumour-expressed antigens, or activation of immune cells.
Many such promising imm…
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