CORDIS Project
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This project investigates the role of cholesterol metabolism in prostate cancer-initiating cells, which are linked to cancer recurrence and therapy resistance. It aims to explore how cholesterol synthesis affects these cells and evaluate the potential of cholesterol synthesis inhibitors as a therapeutic strategy.
According to the WHO, prostate cancer (PCa) is the most common cancer in men in the European Union (EU).
The currentview of cellular transformation and cancer progression supports the notion that cancer cells must undergo a metabolicreprogramming in order to survive in a hostile environment.
Tumors are not homogeneous entities, and most cancers retaina differential fraction of cells with increased self-renewal capability (cancer stem or initiating cells), that accounts forrecurrence and resistan…
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