CORDIS Project
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This project aims to target the oncogenic proteins LIN28, HMGA2, and IGF2BP1 to develop new cancer therapies, particularly for liver and ovarian cancer. By profiling cysteine reactivity and utilizing innovative protein engineering, it seeks to create 'protein drugs' that restore the anti-tumor functions of let-7 microR…
Cancer remains one of the most prevalent diseases worldwide and new therapeutic targets are highly sought.
The oncogenic triangle LIN28/HMGA2/IGF2BP1 is a self-promoting pro-tumorigenic group of proteins with relevant roles in many cancers that antagonize the let-7 family of miRNAs, which possess anti-tumorigenic roles.Activity-based protein profiling applied to the measurement of cysteine reactivity profiles has been efficiently used to profile the landscape of ligandable cysteines in a given p…
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