CORDIS Project
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This project explores a newly discovered protein structure, the alpha-helical barrel, aiming to develop its functionalities. It combines computational design and experimental techniques to engineer binding capabilities and enzyme-like activities within these structures.
Recently through de novo peptide design, we have discovered and presented a new protein structure.
This is an all-parallel, 6-helix bundle with a continuous central channel of 0.5 – 0.6 nm diameter.
We posit that this is one of a broader class of protein structures that we call the alpha-helical barrels.
Here, in three Work Packages, we propose to explore these structures and to develop protein functions within them.
First, through a combination of computer-aided design, peptide synthesis an…
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