CORDIS Project
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This project investigates the neuroprotective effects of BRAWNIN, a mitochondrial protein, using gene therapy. It aims to demonstrate that enhancing BRAWNIN levels can protect neurons from degeneration in diseases like Charcot Marie Tooth disease.
This project will provide proof of concept for the neuroprotective potential of agonists of the mitochondrial protein BRAWNIN.
We have identified that BRAWNIN is an important regulator of mitochondrial function in neurons.
Mitochondria are essential organelles to support metabolic homeostasis in the cell.
Mounting evidence in the literature demonstrate that mitochondria and more broadly metabolic regulation is central to the function of the nervous system.
Axons are especially affected by metabo…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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