CORDIS Project
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The project focuses on Huntington's disease, aiming to identify early biomarkers for monitoring brain changes and cognitive impairments before clinical symptoms appear. It plans to use advanced MRI techniques to assess brain tissue changes and their relationship with behavioral issues.
Huntington’s disease (HD) is a neurodegenerative familial disease encoded by a CAG expansion mutation in the gene that encodes the protein huntingtin (htt).
The abnormal function of mutated htt causes a progressive brain degeneration which in turn causes a sequence of motor, behavioral and cognitive impairment up to dementia.
Even though a genetic test allows preclinical diagnosis many years before the clinical onset, there is no effective therapy to stop the disease to date.
For that reason, th…
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