CORDIS Project
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This project focuses on assembling large molecular machines, like the 26S proteasome, using cryo-electron microscopy maps. It aims to improve the accuracy of molecular models by integrating computational techniques that account for subunit flexibility, ultimately enhancing our understanding of complex biological system…
Proteins are often organized in large, dynamic molecular machines. A mechanistic, atomic-resolution understanding of these machines would provide fundamental insights into the clockwork of the complex machinery underlying human life.
However, machines such as the 26S-proteasome have resisted crystallization attempts for decades.Cryo-electron microscopy (cryo-EM) has provided insightful maps of molecular machines, but these lack atomic resolution.
In principle, molecular machines can be assembled…
TECHNISCHE UNIVERSITAET MUENCHEN
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