CORDIS Project
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The Dendroworld project investigates the immune system's interaction with gut microbiota, focusing on two isoforms of thymic stromal lymphopoietin (TSLP). The goal is to develop a new class of anti-inflammatory drugs based on the anti-inflammatory properties of the short isoform of TSLP to restore immune balance.
Intestinal homeostasis is a complex event that relies on different interactions between the host and the commensal flora, also called microbiota.
The microbiota is a source of gene products that are required for several functions linked to digestion and energy harvest, thus it has to be tolerated, but at the same time controlled.
We have shown that the capacity to tolerate the microbiota is linked to a close interaction between epithelial cells, that are the first line of defence against luminal…
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