CORDIS Project
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This project investigates the mechanisms regulating memory T cells in asthma, focusing on their survival and reactivation in the lung. By utilizing advanced techniques, it aims to identify pathways that could lead to new therapeutic strategies for asthma treatment.
Asthma is the most common chronic lung disease.
In most asthmatics, allergen-specific type-2 CD4 T cells orchestrate allergic airway inflammation by producing type-2 cytokines that ultimately drive asthma pathology.
Studies suggest that a subset of long-lived memory Th2 cells that reside in the lung, known as tissue-resident memory Th2 cells (T2RM), play a significant role in driving asthma chronicity and persistence.
Therapies aimed at depleting T2RM from the lung represent a novel approach to…
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