CORDIS Project
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This project investigates the three-dimensional structure of the Drosophila genome during embryogenesis using advanced chromatin interaction techniques. It aims to uncover the dynamics of enhancer-promoter interactions and their role in gene expression across different cell types.
The mechanisms that regulate genome activation and gene expression occur within a complex three-dimensional (3D) architecture, that helps bring functional regulatory elements into spatial proximity.
Although observed at individual loci, the general principles and dynamics of enhancer-promoter interactions remain very poorly understood.
The proposed project will use chromosome conformation capture, Hi-C, to measure 3D chromatin interactions at a genome-wide scale across different stages of embryo…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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