CORDIS Project
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The 3ITD project investigates the production of natural regulatory T-cells by the thymus in HIV-infected patients. It aims to evaluate the effects of Interleukin-7 as a potential therapy to enhance T-cell diversity and improve immune responses in patients with HIV and those co-infected with hepatitis C.
In developed countries, most HIV-infected patients are under highly active antiretroviral therapy (HAART).
However, despite controlled viral replication, the immune reconstitution often remains incomplete, probably due to a poor reconstitution of thymic production.
Apart its role in educating a diverse repertoire of conventional T-cells, the thymus also produces natural regulatory T-cells (nTreg), which contributes to the regulation of immune responses.
Various cytokines are presently proposed a…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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