CORDIS Project
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This project aims to create a self-patterning 3D human spinal cord model in vitro by utilizing advanced bioengineering techniques and naïve human pluripotent stem cells. It seeks to unlock the mechanisms of spinal cord development and potential regeneration.
Organizers direct formation of the body, releasing morphogens to position tissues and organs.
But what organizes the organizers? I aim to harness organizer formation to build self-patterning 3D human spinal cord in vitro.In developing spinal cord, the floorplate organizer secretes Sonic Hedgehog to direct ventral-dorsal patterning.
Prof Tanaka (secondment) discovered how to recapitulate this in vitro: single mouse naïve pluripotent stem cells (PSCs) form neural tube organoids and an early pulse…
UNIVERSITA DEGLI STUDI DI PADOVA
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