CORDIS Project
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This project aims to clarify the mechanisms behind the homology-directed repair of DNA, focusing on how broken DNA finds matching sequences for repair. It will develop models to understand the dynamics of this process in complex cellular environments.
Homology-directed repair is an essential, evolutionary conserved DNA repair pathway that accurately restores genetic information lost due to double-stranded breaks.
Its key step is the homology search, where the broken DNA end locates its matching sequence, typically located on a sister chromatid, to use as a repair template.
Despite its significance, the biophysical mechanism of this search within the complex environment of vertebrate genomes remains debated.
Emerging hypotheses propose that th…
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
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