CORDIS Project
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This project investigates the molecular events during cell fate conversion processes, focusing on early phases using advanced experimental systems. It aims to understand the dynamics of genome topology and its role in cellular reprogramming, which could enhance therapeutic applications in regenerative medicine.
Cell fate conversion processes bear considerable therapeutic potential yet are poorly understood, and have thus remained slow, inefficient and difficult to translate into medical applications.
The low conversion frequency in current systems, such as classic reprogramming to ‘induced’ pluripotent stem (iPS) cells, has precluded a molecular study of the critical early conversion events.
We propose an interdisciplinary, exhaustive and unbiased approach to unravel the molecular events that accompany…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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