CORDIS Project
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This project investigates the evolution of chromatin structure and regulation in archaea and eukaryotes. By utilizing advanced cryo-electron microscopy, it aims to understand the 3D organization of chromatin and the roles of histone variants and tails in DNA accessibility and compaction.
This proposal brings together the field of chromatin evolution and state-of-the-art structural biology to advance our understanding of a fundamental question: origin of chromatin structural and regulatory complexity.Eukaryotes and most groups of archaea organize their genomes in the form of histone-based chromatin.
Conservation of histones across the tree of life goes beyond protein sequence and histone fold.
Tertiary arrangement of histones and DNA geometry in archaeal nucleosomes resemble thos…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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