CORDIS Project
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This project investigates the arginine vasopressin V2 receptor, a key target for drug development, by characterizing its various active states. The aim is to enhance understanding of its signaling mechanisms, which could lead to new treatments for conditions like hyponatremia and polycystic kidney disease.
G protein-coupled receptors (GPCR) are the largest superfamily of cell surface signaling membrane proteins and the targets of 30% of marketed drugs for many human diseases.
They respond to diverse extracellular stimuli by transmitting the signal across the membrane and activating a number of intracellular signaling pathways.
To sense these stimuli and couple to signaling partners such as G proteins, these transmembrane domains have a high conformational flexibility, representing a challenge for…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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