CORDIS Project
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This project investigates how three-dimensional regulatory landscapes in vertebrate genomes influence gene expression and developmental programs, focusing on gonadal sex determination. By utilizing advanced sequencing and genome editing techniques, it aims to link genomic variations to phenotypic outcomes across differ…
Vertebrate genomes are organized in 3D regulatory landscapes that control pleiotropic gene expression.
Within them, transcription emerges from a precise interplay between genes, regulatory elements and 3D chromatin organization.
We and others have shown how mutations in these regulatory layers can modulate phenotypes.
However, how 3D regulatory landscapes shape the evolutionary history of developmental programs is still largely unexplored.Our limited capability to read, interpret and modify geno…
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
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