CORDIS Project
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This research investigates how cells repair double-stranded DNA breaks and the factors influencing the choice of repair pathways. It aims to understand the spatial organization of DNA within the nucleus and its impact on genome stability, with implications for cancer research.
Faithful repair of double stranded DNA breaks (DSBs) is essential, as they are at the origin of genome instability, chromosomal translocations and cancer.
Cells repair DSBs through different pathways, which can be faithful or mutagenic, and the balance between them at a given locus must be tightly regulated to preserve genome integrity.
Although, much is known about DSB repair factors, how the choice between pathways is controlled within the nuclear environment is not understood.
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THE UNIVERSITY OF SUSSEX
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France, Illkirch Graffenstaden
Type: Research institute
Activity type: Research Organisations
SME: No
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