CORDIS Project
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This project investigates the mechanisms of signaling specificity in eukaryotic cells, focusing on the role of scaffold proteins in mitogen-activated protein kinase pathways. By determining the three-dimensional structures of these complexes in yeast, the project aims to enhance understanding of cellular communication.
Eukaryotic cells contain myriad signaling pathways used to transmit information from the plasma membrane to the nucleus.
Given the large number of pathways in a cell, how is it that a given stimulus leads to a precise response?
This problem is particularly acute in kinase pathways, such as mitogen-activated protein kinase (MAPK) cascades, which often share common protein components.
Over the last decade, however, a paradigm that has emerged is that signaling pathway specificity can be mediated…
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