CORDIS Project
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This project aims to map a comprehensive genetic interaction network in the model organism C. elegans, focusing on how gene mutations interact to influence traits. It seeks to develop methods that can later be applied to predict genetic interactions in humans, enhancing our understanding of hereditary diseases.
Most hereditary diseases in humans are genetically complex, resulting from combinations of mutations in multiple genes.
However synthetic interactions between genes are very difficult to identify in population studies because of a lack of statistical power and we fundamentally do not understand how mutations interact to produce phenotypes. C. elegans is a unique animal in which genetic interactions can be rapidly identified in vivo using RNA interference, and we recently used this system to cons…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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