Closed call · historical reference

H2020-JTI-IMI2-2015-07-two-stage · IDENTIFICATION OF DRUGGABLE TARGETS MODULATING MISFOLDED PROTEINS IN ALZHEIMER’S AND PARKINSON’S DISEASES

Specific Challenge:In Alzheimer’s Disease (AD) extracellular depositions of amyloid beta peptides (plaques) and intracellular filamentous inclusions of tau (tangles) constitutes a hallmark of the disease. In Parkinson’s Disease (PD) the neuropathology is defined by intracellular inclusions of alpha…