Supporting the implementation of the Cancer Mission · Leveraging functional genomics to reveal novel targets for cancer treatment

Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to all of the following expected outcomes: • Researchers and health professionals gain a deeper understanding of the functional effects of tumour heterogeneity during cancer initiation and progression, supporting the identification of more precise and novel therapeutic targets. • Researchers, health professionals and innovators benefit from improved knowledge and…

The proposed topic will contribute to the EU Cancer Mission objective of improving the understanding of cancer initiation and progression. Of particular interest for this topic are paediatric and adolescent cancers[1] , cancers with limited treatment options, refractory cancers, rare cancers or cancer types with low five-year survival rates. Proposals may include the design of exploratory mechanistic studies using longitudinal patient bio-samples, clinical proof-of-concept…